ModSeqR is an R package developed by Wasatch Biolabs for efficient preprocessing, summarization, and visualization of methylation data. It supports native DNA methylation sequencing workflows and is optimized for high-throughput pipelines.
Features
- Database-backed storage using DuckDB - Sliding window, positional, regional, and read-level summarization of methylation levels - Support for multiple methylation contexts - Quality Control Visualization - Efficient Differential Methylation Analysis
References
Wasatch Biolabs (2025). *ModSeqR: Tools for Methylation Analysis in Clinical and Research Settings.* https://www.wasatchbiolabs.com/
For bug reports and feature requests: https://github.com/Wasatch-Biolabs-Bfx/ModSeqR
Author
Jonathon Hill jonathon@wasatchbiolabs.com (aut, cre) Hailey Zimmerman hailey@renewbt.com (aut)